Back in 1990, the National Institutes of Health began funding a long-term study of stroke and cardiovascular risk factors among of urban adults. Known as the Northern Manhattan Study and housed at Columbia University, the project enrolled thousands of people from the community and subjected them to medical testing while recording their food-consumption habits.
Among its results, a surprising one has emerged (recently published paper available here): people who drink at least one diet soda a day are 43 percent more likely to experience a “vascular event”—i.e., strokes and heart attacks—than people who drink none.
Now, it’s important to understand that studies like this one establish correlation, not causation. It’s possible that the heart trouble experienced by diet soda drinkers comes from some other behavior they share that has nothing to do with diet soda.
But crucially, this study accounted for factors like weight, diabetes, high blood pressure, and intake of calories, cholesterol, and sodium, study author and University of Miami epidemiologist Hannah Gardener told me in a phone conversation. In other words, non-overweight diet soda drinkers showed significantly more risk of heart attack than non-overweight people who don’t drink diet soda.
The Manhattan results comes on the heels of other highly suggestive research showing an association between diet-soda consumption and type 2 (adult onset) diabetes and metabolic syndrome, a condition characterized by abdominal obesity, high blood pressure, and other factors.