Let’s remember what community organizing and public service look like, for just a moment. In addition to the announcement that the Obamas will personally donate $2 million to Chicago Jobs for Youth programs, they released plans for the “campus” at the Obama Foundation center along Lake Michigan. Chicago Sun Times: The former first couple envision the… Continue Reading →
Every once in a while, the Catholics step up:
The recent amendments to the bill, intended to make it more palatable to those who did not support it initially, are even more disastrous for people who have just gotten health care. Changing the current rules to undermine essential benefits requirements and protections for people with pre-existing conditions, as well as allowing insurers to set annual and life time caps on the care they cover, would seriously undermine health security and leave many individuals with substandard protection. Even the proposed state high-risk pools would be an inadequate and under-funded solution to a problem that need not exist in the first place.
It is critically important to look at this bill for what it is. It is not in any way a health care bill. Rather, it is legislation whose aim is to take significant funding allocated by Congress for health care for very low income people and use that money for tax cuts for some of our wealthiest citizens. This is contrary to the spirit of who we are as a nation, a giant step backward that should be resisted.
The Rev. William Barber, architect of North Carolina’s Moral Mondays, lifts us up:
“I need you to turn to your neighbor and say, ‘Neighbor, Nebuchadnezzar is scared of you.’ That’s why he’s trying to get you to bow. ‘Cause he knows that if you stand, it’ll be all right.
“There’s strength in our standing.
“I stopped by to tell you we may be headed into some fiery times. But bowing down is not an option. Falling down is not an option. Looking down is not an option.
“We can’t bow until justice comes. We can’t bow until mercy comes. We can’t bow until the glory comes.
“Now, one day, we’ll be able to bow. When every heel is made low, and the rough places are made smooth, and the crooked places are made straight, and the glory of the Lord is revealed — I’m bowing then.
“But until then,
Bowing is not an option.”
Now watch the video. You’ll feel better.
Robert Persig, 88. Author of Zen and the Art of Motorcycle Maintenance, one of my favorite books.
“Zen” is the account of a 1968 motorcycle trip that Pirsig, his 11-year-old son Chris and two friends made from Minneapolis through the West. A fifth traveler was sensed but unseen: Phaedrus, Pirsig’s alter ego, brilliant, uncompromising and obsessed with the search for truth. Like the real-life Pirsig, the ghost-like Phaedrus had an IQ of 170, entered a university at 15 and, as a young man, was committed to mental hospitals where he underwent electroconvulsive therapy.
“He was dead,” Pirsig’s narrator writes in “Zen.” “Destroyed by order of the court, enforced by the transmission of high-voltage alternating current through the lobes of his brain.”
On the trip, though, the “dead” Phaedrus was all too active, a real but intangible force vying for the soul of the emotionally unstable Chris. Chris is spared in the novel, but Pirsig’s actual son Chris struggled with drug addiction and, at 22, was stabbed to death during a 1979 mugging in San Francisco. It was at a bus stop near the Zen Buddhism center where he lived.
While the book has a more or less happy ending, “Zen” is filled with unanswered and, perhaps, unanswerable questions. Pirsig, who weathered schizophrenia but was devastated by its treatment, doubts everything: reality, sanity — and himself.
“What I am,” he writes, “is a heretic who’s recanted and thereby in everyone’s eyes saved his soul. Everyone’s eyes but one, who knows deep down inside that all he has saved is his skin.”
A chemical weapons attack that killed more than 80 people, including children, triggered the Trump administration’s recent missile strikes against the Syrian government. The use of illegal nerve agents – apparently by the Assad regime – violated international law; President Trump said he was moved to act by images of the victims’ horrible deaths.
But there’s another path to mitigate the danger of chemical weapons. This route lies within the domains of science – the very same science that produced chemical weapons in the first place. Researchers in the U.S. and around the world, including here at the University of Washington’s Institute for Protein Design, are developing the tools needed to quickly and safely destroy nerve agents – both in storage facilities and in the human body.
Nerve agents, a class of synthetic phosphorous-containing compounds, are among the most toxic substances known. Brief exposure to the most potent variants can lead to death within minutes. Once nerve agents enter the body, they irreversibly inhibit a vitally important enzyme called acetylcholinesterase. Its normal job within the nervous system is to help brain and muscle communicate. When a nerve agent shuts down this enzyme, classes of neurons throughout the central and peripheral nervous systems quickly get overstimulated, leading to profuse sweating, convulsions and an excruciating death by asphyxiation.
Chemical weapons are often associated with wars of the previous century – mustard gas in WWI, Zyklon B in WWII. But the worst variety, nerve agents, were never deployed in the world wars, though Nazi scientists developed the first generation of these compounds. Gerhard Schrader, the so-called father of nerve agents, didn’t begin life as a Nazi scientist – he was developing new pesticides to combat world hunger when he accidentally synthesized the first organophosphorus nerve agent. Later, he led the research team that produced sarin, or GB, the most toxic of the all the so-called G-series nerve agents. The U.S. government stated with “very high confidence” that sarin was used in the recent attack near Idlib, Syria.
Beginning in 2013, teams from the Organization for the Prohibition of Chemical Weapons went to Syria and, with help from the Danish, Norwegian, Russian, Chinese and U.S. government, destroyed all declared stockpiles of Syrian chemical weapons. It seems that either not all of Assad’s stockpiles were in fact declared and destroyed, or that new nerve agents arrived in Syria – either via the black market or chemical synthesis – in the intervening years.
Clearing chemical weapons
Twenty-first-century chemists, biochemists and computer scientists are working right now to sap chemical weapons of their horrifying power by designing counter agents that safely and efficiently destroy them.
Sarin sitting in a container – as opposed to in a human body – is relatively easy to destroy. The simplest method is to add a soluble base and heat the mixture to near-boiling temperatures. After several hours, the vast majority – more than 99.9 percent – of the deadly compound can be broken apart by a process called hydrolysis. This is how trained specialists dispose of chemical weapons like sarin.
Nerve agents that make their way inside the body are a different story. For starters, you clearly cannot add a near-boiling base to a person. And because nerve agents kill so quickly, any treatment that takes hours to work is a nonstarter.
There are chemical interventions for warding off death after exposure to certain chemical weapons. Unfortunately, these interventions are costly, difficult to dose properly and are themselves quite toxic. The chemical antidotes pralidoxime and the cheaper atropine were deployed after recent attacks in Syria, but doctors in the area worry their dwindling supplies offer little protection against possible future attacks.
For a medical intervention to work after nerve gas exposure, it has to work fast. If a first responder administers a sarin-destroying molecule, each therapeutic molecule must be capable of breaking down through hydrolysis hundreds of nerve agent molecules per second, one after another.
Enzymes, the genetically encoded catalysts of biology, are up for such a task. Famous enzymes include lactase, which breaks down milk sugars in those who are lactose tolerant. Another known as RuBisCO is vital to the process of carbon fixation in plants. The most efficient enzymes in your body can perform a million reactions per second, and do so under chemically mild conditions.
Aside from their astonishing speed, enzymes often display an equally impressive selectivity. That is, they react with only a small number of structurally similar compounds and leave all other compounds alone. Selectivity is useful in the context of the chemical soup that is the cell but problematic when it comes to xenobiotics: those compounds which are foreign to one’s biology. Man-made organophosphates such as sarin are xenobiotics. There are no enzymes that hydrolyze them well – or so we thought.
When farmers spray pesticides, much of it ends up on the ground. Soil bacteria living nearby are challenged by high doses of these potent foreign chemicals. It turns out that efficient detoxifying enzymes have recently evolved inside some of these microbes as a result.
Scientists have identified and isolated a small number of these enzymes and tested them on a range of nasty compounds, including nerve agents, which are structurally similar to some pesticides. A select few did indeed show hydrolytic activity.
Improving on the discovery
Researchers have taken these naturally occurring enzymes as raw material. Then, using computer modeling and controlled evolution in the lab, we’ve bolstered the efficiency of the originally found anti-nerve agent enzymes. Enzymes that initially showed only modest activity have been turned into potential therapeutics against VX – a chemical cousin of sarin and the most toxic nerve agent of all.
In a proof-of-concept study conducted jointly by researchers in Germany and Israel in late 2014, guinea pigs under anesthesia were exposed to lethal doses of VX, followed by optimized VX-destroying proteins. Low doses of the protein drug, even after a 15-minute delay, resulted in survival of all animals and only moderate toxicity.
Despite these promising advances, no enzyme yet exists which is efficient enough for lifesaving use in people. Scientists are refining these microscopic machines, and new paradigms in computer-aided protein engineering are unlocking the door to this and other applications of biomolecular design. We may be only a few years away from developing the kind of therapeutics that would make chemical weapons a worry of the past.
As the world grieves over the latest attacks in Syria, it is worth keeping in mind the awesome and often complex power of science. In trying to combat hunger, one might accidentally invent liquid death. In studying soil microbes, one might discover a tool to prevent atrocities.
A new generation of recycling has now gone from local drop-off centers to a shopping mall that sells only repaired or upcycled products. The new recycling establishment, ReTuna Återbruksgalleria, has nothing to do with the fish; instead, it was named after the Swedish town in which the building is located, Eskilstuna, Sweden. style=”display:inline-block;width:300px;height:250px” data-ad-client=”ca-pub-8420654331411867″ data-ad-slot=”1313712966″> The… Continue Reading →
Early morning, April 4
Shot rings out in the Memphis sky
Free at last
They took your life
They could not take your pride.
Jimmy Breslin, 86. Author, Pulitzer winner, newspaper columnist, and my hero and role model.
This was his most famous column.
The one he wrote after John Lennon was shot.
Ashley Jordan and her husband Michael do all of their shopping at Walmart every two weeks – but they have apparently never encountered as compassionate a cashier as Sharnique Dasant. The couple, who are the proud parents of three children, were loading up two shopping carts worth of groceries and baby clothes at a Walmart in… Continue Reading →
You may remember Jay, a long-time reader here. And like many of us, he’s in a place where one financial catastrophe (a broken transmission) may snowball into many others. We’ve all been there, right?
Couple of years back I bought a nice very used 1999 model Ford car from a man here in town for $1500. I don’t drive much, and I have tried to be gentle with it but things eventually wear out. This morning the transmssion broke down and will cost over $1000 to fix. I need to raise enough to repair it or buy another used car from the place I got this one.
I am 67 years old and my main income is Social Security, (less than $900 a month) and two night classes I teach for Marshall University. If you can help me get back on the road, I will be very grateful. I am totally on foot right now, so time is of the essence. I live a mile out of town, and I have to walk over the hill to get any supplies.
I spent my prime earning years as a minister and did not accumulate any assets for my “golden years”. Also I spent the last 15 years caring for my elderly mother until she died in September 2015. When she died I lost 2/3 of my income and it has been a struggle ever since to get by.
It’s my late mother’s birthday. My mom was one of those people who worried about everybody, and I know if she was still here, she’d want to help. It would be nice if we could all chip in and help Jay.
If you can spare even $5, please contribute to his GoFundMe page.